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The intrinsic solubility of a molecule is the maximum amount of the neutral compound that can dissolve, excluding any (de)protonation events

3.3.3 Altered fatty acid metabolism affecting follicular growth HFD disrupts ovarian fatty acid metabolism by upregulating fatty acid uptake and trafficking (increased CD36, FABP expression), impairing -oxidation (reduced PPAR targets, CPT1, ACOX), and promoting lipid storage via PPAR-mediated FSP27/CIDE-C upregulation, leading to ectopic lipid accumulation, lipotoxicity, and oxidative stress compromising folliculogenesis at multiple stages (Di Berardino et al., 2022) (Yan et al., 2020

There are ten primary lobules that are separated from one another by a series of fissures [2]

doi:10.1186/s40425-016-0152-y Hodi, F.S., ODay, S.J., McDermott, D.F., Weber, R.W., Sosman, J.A., Haanen, J.B.,